A phase 2 clinical trial of a novel therapy for patients who have experienced a relapse of diffuse large B-cell lymphoma (DLBCL) resulted in extended remission, averaging 14.5 months, and longer than three years in exceptional cases. The drug, which targets histone-modifying enzymes (HME), was shown to be effective against a particular genetic mutation. The trial was initiated, designed, and coordinated by Dr. Sarit Assouline, a hematologist oncologist at the Segal Cancer Centre at the Jewish General Hospital and clinician-scientist at the Lady Davis Institute. The results were published in Blood.
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